Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation

Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hematopoietic niche is regulated by a signaling axis using Hedgehog (Hh) and Notch, which culminates in expression of Runx1 in the ventral wall of the artery. Here, we demon...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Cortes, Mauricio, Liu, Sarah Y., Kwan, Wanda, Alexa, Kristen, Goessling, Wolfram, North, Trista E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624955/
https://ncbi.nlm.nih.gov/pubmed/26365513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.08.010
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