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RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells

Mesenchymal stem cells (MSC) are suggested to be important progenitors of myofibroblasts in fibrosis. To understand the role of Rho GTPase signaling in TGFβ-induced myofibroblast differentiation of MSC, we generated a novel MSC line and its descendants lacking functional Rho GTPases and Rho GTPase s...

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Publicat a:J Biol Chem
Autors principals: Ge, Jianfeng, Burnier, Laurent, Adamopoulou, Maria, Kwa, Mei Qi, Schaks, Matthias, Rottner, Klemens, Brakebusch, Cord
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005422/
https://ncbi.nlm.nih.gov/pubmed/29700112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001113
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