Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

[Image: see text] Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g., ALDH1A...

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Τόπος έκδοσης:J Med Chem
Κύριοι συγγραφείς: Yang, Shyh-Ming, Martinez, Natalia J., Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q., Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S., Roth, Jacob, Lal-Nag, Madhu, Dunford, James E., Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2018
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004562/
https://ncbi.nlm.nih.gov/pubmed/29767973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00270
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