Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes

Xerostomia (dry mouth) is the most common side effect of radiation therapy in patients with head and neck cancer and causes difficulty speaking and swallowing. Since aldehyde dehydrogenase 3A1 (ALDH3A1) is highly expressed in mouse salivary stem/progenitor cells (SSPCs), we sought to determine the r...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Saiki, Julie P., Cao, Hongbin, Van Wassenhove, Lauren D., Viswanathan, Vignesh, Bloomstein, Joshua, Nambiar, Dhanya K., Mattingly, Aaron J., Jiang, Dadi, Chen, Che-Hong, Stevens, Matthew C., Simmons, Amanda L., Park, Hyun Shin, von Eyben, Rie, Kool, Eric T., Sirjani, Davud, Knox, Sarah M., Le, Quynh Thu, Mochly-Rosen, Daria
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004437/
https://ncbi.nlm.nih.gov/pubmed/29794221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802184115
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