Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes

Xerostomia (dry mouth) is the most common side effect of radiation therapy in patients with head and neck cancer and causes difficulty speaking and swallowing. Since aldehyde dehydrogenase 3A1 (ALDH3A1) is highly expressed in mouse salivary stem/progenitor cells (SSPCs), we sought to determine the r...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Saiki, Julie P., Cao, Hongbin, Van Wassenhove, Lauren D., Viswanathan, Vignesh, Bloomstein, Joshua, Nambiar, Dhanya K., Mattingly, Aaron J., Jiang, Dadi, Chen, Che-Hong, Stevens, Matthew C., Simmons, Amanda L., Park, Hyun Shin, von Eyben, Rie, Kool, Eric T., Sirjani, Davud, Knox, Sarah M., Le, Quynh Thu, Mochly-Rosen, Daria
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004437/
https://ncbi.nlm.nih.gov/pubmed/29794221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802184115
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