α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

Dopaminergic neurodegeneration in Parkinson's disease (PD) is associated with abnormal dopamine metabolism by MAO‐B (monoamine oxidase‐B) and intracellular α‐Synuclein (α‐Syn) aggregates, called the Lewy body. However, the molecular relationship between α‐Syn and MAO‐B remains unclear. Here, we...

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Pubblicato in:EMBO J
Autori principali: Kang, Seong Su, Ahn, Eun Hee, Zhang, Zhentao, Liu, Xia, Manfredsson, Fredric P, Sandoval, Ivette M, Dhakal, Susov, Iuvone, P Michael, Cao, Xuebing, Ye, Keqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003650/
https://ncbi.nlm.nih.gov/pubmed/29769405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798878
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