α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

Dopaminergic neurodegeneration in Parkinson's disease (PD) is associated with abnormal dopamine metabolism by MAO‐B (monoamine oxidase‐B) and intracellular α‐Synuclein (α‐Syn) aggregates, called the Lewy body. However, the molecular relationship between α‐Syn and MAO‐B remains unclear. Here, we...

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Vydáno v:EMBO J
Hlavní autoři: Kang, Seong Su, Ahn, Eun Hee, Zhang, Zhentao, Liu, Xia, Manfredsson, Fredric P, Sandoval, Ivette M, Dhakal, Susov, Iuvone, P Michael, Cao, Xuebing, Ye, Keqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003650/
https://ncbi.nlm.nih.gov/pubmed/29769405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798878
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