STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein subunit vaccine elicit long-lasting protective immunity to My...

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Udgivet i:Cell Rep
Main Authors: Van Dis, Erik, Sogi, Kimberly M., Rae, Chris S., Sivick, Kelsey E., Surh, Natalie H., Leong, Meredith L., Kanne, David B., Metchette, Ken, Leong, Justin J., Bruml, Jacob R., Chen, Vivian, Heydari, Kartoosh, Cadieux, Nathalie, Evans, Tom, McWhirter, Sarah M., Dubensky, Thomas W., Portnoy, Daniel A., Stanley, Sarah A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003617/
https://ncbi.nlm.nih.gov/pubmed/29719256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.003
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