Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

Our study demonstrates that Pt(iv) derivative of cisplatin, with two axial PhB ligands, ctc-[Pt(NH(3))(2)(PhB)(2)Cl(2)], is a very potent cytotoxic agent against many different human cancer cell lines and is up to 100 fold more potent than cisplatin, and significantly more potent than the Pt(iv) der...

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Pubblicato in:Chem Sci
Autori principali: Raveendran, Raji, Braude, Jeremy Phillip, Wexselblatt, Ezequiel, Novohradsky, Vojtech, Stuchlikova, Olga, Brabec, Viktor, Gandin, Valentina, Gibson, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2016
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003606/
https://ncbi.nlm.nih.gov/pubmed/29997781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04205d
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