Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

Our study demonstrates that Pt(iv) derivative of cisplatin, with two axial PhB ligands, ctc-[Pt(NH(3))(2)(PhB)(2)Cl(2)], is a very potent cytotoxic agent against many different human cancer cell lines and is up to 100 fold more potent than cisplatin, and significantly more potent than the Pt(iv) der...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Raveendran, Raji, Braude, Jeremy Phillip, Wexselblatt, Ezequiel, Novohradsky, Vojtech, Stuchlikova, Olga, Brabec, Viktor, Gandin, Valentina, Gibson, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003606/
https://ncbi.nlm.nih.gov/pubmed/29997781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04205d
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