Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

Our study demonstrates that Pt(iv) derivative of cisplatin, with two axial PhB ligands, ctc-[Pt(NH(3))(2)(PhB)(2)Cl(2)], is a very potent cytotoxic agent against many different human cancer cell lines and is up to 100 fold more potent than cisplatin, and significantly more potent than the Pt(iv) der...

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Vydáno v:Chem Sci
Hlavní autoři: Raveendran, Raji, Braude, Jeremy Phillip, Wexselblatt, Ezequiel, Novohradsky, Vojtech, Stuchlikova, Olga, Brabec, Viktor, Gandin, Valentina, Gibson, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2016
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003606/
https://ncbi.nlm.nih.gov/pubmed/29997781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04205d
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