Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene...

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Pubblicato in:Bioinorg Chem Appl
Autori principali: Nosova, Yulia N., Zenin, Ilia V., Maximova, Varvara P., Zhidkova, Ekaterina M., Kirsanov, Kirill I., Lesovaya, Ekaterina A., Lobas, Anna A., Gorshkov, Mikhail V., Kovaleva, Olga N., Milaeva, Elena R., Galanski, Markus, Keppler, Bernhard K., Nazarov, Alexey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540250/
https://ncbi.nlm.nih.gov/pubmed/28804273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4736321
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