Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene...

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Detalhes bibliográficos
Publicado no:Bioinorg Chem Appl
Main Authors: Nosova, Yulia N., Zenin, Ilia V., Maximova, Varvara P., Zhidkova, Ekaterina M., Kirsanov, Kirill I., Lesovaya, Ekaterina A., Lobas, Anna A., Gorshkov, Mikhail V., Kovaleva, Olga N., Milaeva, Elena R., Galanski, Markus, Keppler, Bernhard K., Nazarov, Alexey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540250/
https://ncbi.nlm.nih.gov/pubmed/28804273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4736321
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