Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

A series of triple action Pt(iv) prodrugs was designed to test the hypothesis that multi-action compounds, where each bioactive moiety intervenes in several cellular processes, might be more effective than a single agent at killing cancer cells. In particular, “triple action” Pt(iv) derivatives of c...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Petruzzella, Emanuele, Sirota, Roman, Solazzo, Irene, Gandin, Valentina, Gibson, Dan
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944384/
https://ncbi.nlm.nih.gov/pubmed/29780561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc00428e
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