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cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis

In response to cold exposure, placental mammals maintain body temperature by increasing sympathetic nerve activity in brown adipose tissue (BAT). Triggering of β-adrenergic receptors on brown adipocytes stimulates thermogenesis via induction of the cAMP/PKA pathway. Although cAMP response element-bi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yoon, Young-Sil, Tsai, Wen-Wei, Van de Velde, Sam, Chen, Zhijiang, Lee, Kuo-Fen, Morgan, Donald A., Rahmouni, Kamal, Matsumura, Shigenobu, Wiater, Ezra, Song, Youngsup, Montminy, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003335/
https://ncbi.nlm.nih.gov/pubmed/29784793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805257115
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