Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

A protein synthesis enzyme, leucyl-tRNA synthetase (LRS), serves as a leucine sensor for the mechanistic target of rapamycin complex 1 (mTORC1), which is a central effector for protein synthesis, metabolism, autophagy, and cell growth. However, its significance in mTORC1 signaling and cancer growth...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Minji, Kim, Jong Hyun, Yoon, Ina, Lee, Chulho, Fallahi Sichani, Mohammad, Kang, Jong Soon, Kang, Jeonghyun, Guo, Min, Lee, Kang Young, Han, Gyoonhee, Kim, Sunghoon, Han, Jung Min
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003318/
https://ncbi.nlm.nih.gov/pubmed/29784813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801287115
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