Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well understood. Here, we demonstrate that the leucine sensor function for mTORC1 activation of LRS...

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Published in:Nat Commun
Main Authors: Kim, Jong Hyun, Lee, Chulho, Lee, Minji, Wang, Haipeng, Kim, Kibum, Park, Seung Joon, Yoon, Ina, Jang, Jayun, Zhao, Hanchao, Kim, Hoi Kyoung, Kwon, Nam Hoon, Jeong, Seung Jae, Yoo, Hee Chan, Kim, Jae Hyun, Yang, Jee Sun, Lee, Myeong Youl, Lee, Chang Woo, Yun, Jieun, Oh, Soo Jin, Kang, Jong Soon, Martinis, Susan A., Hwang, Kwang Yeon, Guo, Min, Han, Gyoonhee, Han, Jung Min, Kim, Sunghoon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622079/
https://ncbi.nlm.nih.gov/pubmed/28963468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00785-0
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