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Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling
Amino acid availability activates signaling by the mammalian target of rapamycin (mTOR) complex 1, mTORC1, a master regulator of cell growth. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocation and activation of the phospholipase PLD1. Here w...
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| I publikationen: | Cell Rep |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4981521/ https://ncbi.nlm.nih.gov/pubmed/27477288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.008 |
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