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A current structural perspective on PXR and CAR in drug metabolism

INTRODUCTION: Pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that play major roles in the expression of various drug metabolism enzymes and are known for their ligand promiscuity. As with other nuclear receptors, PXR and C...

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Detalhes bibliográficos
Publicado no:Expert Opin Drug Metab Toxicol
Main Authors: Buchman, Cameron D., Chai, Sergio C., Chen, Taosheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002932/
https://ncbi.nlm.nih.gov/pubmed/29757018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17425255.2018.1476488
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