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PXR variants: the impact on drug metabolism and therapeutic responses
The pregnane X receptor (PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters. Several protein isoforms of PXR exist, and they have differential transcriptional activity upon target genes; transcript variants 3 (PXR3) and 4 (PXR4) d...
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| Foilsithe in: | Acta Pharm Sin B |
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| Main Authors: | , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Elsevier
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045535/ https://ncbi.nlm.nih.gov/pubmed/27709012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.07.002 |
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