Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

Antiretroviral drug (ARV) metabolism is linked largely to hepatic cytochrome P450 activity. One ARV drug class known to be metabolized by intestinal and hepatic CYP3A are the protease inhibitors (PIs). Plasma drug concentrations are boosted by CYP3A inhibitors such as cobisistat and ritonavir (RTV)....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Pharmacol Exp Ther
Päätekijät: McMillan, JoEllyn M., Cobb, Denise A., Lin, Zhiyi, Banoub, Mary G., Dagur, Raghubendra S., Branch Woods, Amanda A., Wang, Weimin, Makarov, Edward, Kocher, Ted, Joshi, Poonam S., Quadros, Rolen M., Harms, Donald W., Cohen, Samuel M., Gendelman, Howard E., Gurumurthy, Channabasavaiah B., Gorantla, Santhi, Poluektova, Larisa Y.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2018
Aiheet:
Metabolism, Transport, and Pharmacogenomics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878674/
https://ncbi.nlm.nih.gov/pubmed/29476044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.247288
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia