Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

Antiretroviral drug (ARV) metabolism is linked largely to hepatic cytochrome P450 activity. One ARV drug class known to be metabolized by intestinal and hepatic CYP3A are the protease inhibitors (PIs). Plasma drug concentrations are boosted by CYP3A inhibitors such as cobisistat and ritonavir (RTV)....

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: McMillan, JoEllyn M., Cobb, Denise A., Lin, Zhiyi, Banoub, Mary G., Dagur, Raghubendra S., Branch Woods, Amanda A., Wang, Weimin, Makarov, Edward, Kocher, Ted, Joshi, Poonam S., Quadros, Rolen M., Harms, Donald W., Cohen, Samuel M., Gendelman, Howard E., Gurumurthy, Channabasavaiah B., Gorantla, Santhi, Poluektova, Larisa Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878674/
https://ncbi.nlm.nih.gov/pubmed/29476044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.247288
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