Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

Antiretroviral drug (ARV) metabolism is linked largely to hepatic cytochrome P450 activity. One ARV drug class known to be metabolized by intestinal and hepatic CYP3A are the protease inhibitors (PIs). Plasma drug concentrations are boosted by CYP3A inhibitors such as cobisistat and ritonavir (RTV)....

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: McMillan, JoEllyn M., Cobb, Denise A., Lin, Zhiyi, Banoub, Mary G., Dagur, Raghubendra S., Branch Woods, Amanda A., Wang, Weimin, Makarov, Edward, Kocher, Ted, Joshi, Poonam S., Quadros, Rolen M., Harms, Donald W., Cohen, Samuel M., Gendelman, Howard E., Gurumurthy, Channabasavaiah B., Gorantla, Santhi, Poluektova, Larisa Y.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
Fag:
Metabolism, Transport, and Pharmacogenomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878674/
https://ncbi.nlm.nih.gov/pubmed/29476044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.247288
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