Combination therapy of lovastatin and AMP‐activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model

Recent studies report that loss and dysfunction of mitochondria and peroxisomes contribute to the myelin and axonal damage in multiple sclerosis (MS). In this study, we investigated the efficacy of a combination of lovastatin and AMP‐activated protein kinase (AMPK) activator (AICAR) on the loss and...

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Bibliographische Detailangaben
Veröffentlicht in:Immunology
Hauptverfasser: Singh, Inderjit, Samuvel, Devadoss J., Choi, Seungho, Saxena, Nishant, Singh, Avtar K., Won, Jeseong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002225/
https://ncbi.nlm.nih.gov/pubmed/29331024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12893
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