Combination therapy of lovastatin and AMP‐activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model

Recent studies report that loss and dysfunction of mitochondria and peroxisomes contribute to the myelin and axonal damage in multiple sclerosis (MS). In this study, we investigated the efficacy of a combination of lovastatin and AMP‐activated protein kinase (AMPK) activator (AICAR) on the loss and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Immunology
Auteurs principaux: Singh, Inderjit, Samuvel, Devadoss J., Choi, Seungho, Saxena, Nishant, Singh, Avtar K., Won, Jeseong
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002225/
https://ncbi.nlm.nih.gov/pubmed/29331024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12893
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