AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis

Sphingosine-1-phosphate receptor 1 (S1P1) mediated regulation of lymphocyte egress from lymphoid organs is recognized as the mechanism of FTY720 (Fingolimod, Gilenya) efficacy in relapsing-remitting forms of multiple sclerosis (RRMS). In this study we describe a novel S1P1 agonist AKP-11, next gener...

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Pubblicato in:PLoS One
Autori principali: Samuvel, Devadoss J., Saxena, Nishant, Dhindsa, Jasdeep S., Singh, Avtar K., Gill, Gurmit S., Grobelny, Damian W., Singh, Inderjit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626178/
https://ncbi.nlm.nih.gov/pubmed/26513477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141781
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