Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model

Intervertebral disc degeneration (IVDD) is a chronic disease with complicated pathology involving nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) degradation. Previous studies have shown that moderate autophagy has a protective effect against apoptosis in NP cells. Berberine (BBR...

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Bibliografiske detaljer
Udgivet i:Int J Biol Sci
Main Authors: Chen, Yu, Zheng, Zengming, Wang, Jianle, Tang, Chengxuan, Khor, Sinan, Chen, Jian, Chen, Xibang, Zhang, Zengjie, Tang, Qian, Wang, Chenggui, Lou, Yiting, Wang, Zhouguang, Xiao, Jian, Wang, Xiangyang
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001656/
https://ncbi.nlm.nih.gov/pubmed/29904282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.24081
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