Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

Intervertebral disc degeneration (IDD) is a complicated disease in patients. The pathogenesis of IDD encompasses cellular oxidative stress, mitochondrion dysfunction and apoptosis. Melatonin eliminates oxygen free radicals, regulates mitochondrial homoeostasis and function, stimulates mitophagy and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Mol Med
Main Authors: Chen, Yu, Wu, Yanqing, Shi, Hongxue, Wang, Jianle, Zheng, Zengming, Chen, Jian, Chen, Xibang, Zhang, Zengjie, Xu, Daoliang, Wang, Xiangyang, Xiao, Jian
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378230/
https://ncbi.nlm.nih.gov/pubmed/30609271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14125
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