FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...

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Pubblicato in:eLife
Autori principali: Dimitrova, Emilia, Kondo, Takashi, Feldmann, Angelika, Nakayama, Manabu, Koseki, Yoko, Konietzny, Rebecca, Kessler, Benedikt M, Koseki, Haruhiko, Klose, Robert J
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Chromosomes and Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997449/
https://ncbi.nlm.nih.gov/pubmed/29809150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37084
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