FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Dimitrova, Emilia, Kondo, Takashi, Feldmann, Angelika, Nakayama, Manabu, Koseki, Yoko, Konietzny, Rebecca, Kessler, Benedikt M, Koseki, Haruhiko, Klose, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997449/
https://ncbi.nlm.nih.gov/pubmed/29809150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37084
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