FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Dimitrova, Emilia, Kondo, Takashi, Feldmann, Angelika, Nakayama, Manabu, Koseki, Yoko, Konietzny, Rebecca, Kessler, Benedikt M, Koseki, Haruhiko, Klose, Robert J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2018
Gaiak:
Chromosomes and Gene Expression
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997449/
https://ncbi.nlm.nih.gov/pubmed/29809150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37084
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