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KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

CpG islands (CGIs) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based mechanisms, however in most cases this has not been directly tested. Here, we...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Turberfield, Anne H, Kondo, Takashi, Nakayama, Manabu, Koseki, Yoko, King, Hamish W, Koseki, Haruhiko, Klose, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753492/
https://ncbi.nlm.nih.gov/pubmed/31363749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz607
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