Rational library design by functional CDR resampling

Successful antibody discovery relies on diversified libraries, where two aspects are implied, namely the absolute number of unique clones and the percentage of functional clones. Instead of pursuing the absolute quantity thresholded by current display technology, we have sought to maximize the effec...

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Dettagli Bibliografici
Pubblicato in:N Biotechnol
Autori principali: Zhao, Qi, Buhr, Diane, Gunter, Courtney, Frenette, Jenny, Ferguson, Mary, Sanford, Eric, Holland, Erika, Rajagopal, Chitra, Batonick, Melissa, Kiss, Margaret M., Weiner, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995609/
https://ncbi.nlm.nih.gov/pubmed/29242049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbt.2017.12.005
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