Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Molecular pro...

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Bibliografiska uppgifter
I publikationen:Stem Cell Reports
Huvudupphovsmän: Ohashi, Minori, Korsakova, Elena, Allen, Denise, Lee, Peiyee, Fu, Kai, Vargas, Benni S., Cinkornpumin, Jessica, Salas, Carlos, Park, Jenny C., Germanguz, Igal, Langerman, Justin, Chronis, Contantinos, Kuoy, Edward, Tran, Stephen, Xiao, Xinshu, Pellegrini, Matteo, Plath, Kathrin, Lowry, William E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2018
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Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995366/
https://ncbi.nlm.nih.gov/pubmed/29742391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.001
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