Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Molecular pro...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Ohashi, Minori, Korsakova, Elena, Allen, Denise, Lee, Peiyee, Fu, Kai, Vargas, Benni S., Cinkornpumin, Jessica, Salas, Carlos, Park, Jenny C., Germanguz, Igal, Langerman, Justin, Chronis, Contantinos, Kuoy, Edward, Tran, Stephen, Xiao, Xinshu, Pellegrini, Matteo, Plath, Kathrin, Lowry, William E.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995366/
https://ncbi.nlm.nih.gov/pubmed/29742391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.001
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