Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Molecular pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Ohashi, Minori, Korsakova, Elena, Allen, Denise, Lee, Peiyee, Fu, Kai, Vargas, Benni S., Cinkornpumin, Jessica, Salas, Carlos, Park, Jenny C., Germanguz, Igal, Langerman, Justin, Chronis, Contantinos, Kuoy, Edward, Tran, Stephen, Xiao, Xinshu, Pellegrini, Matteo, Plath, Kathrin, Lowry, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995366/
https://ncbi.nlm.nih.gov/pubmed/29742391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados