Epigenetic dysregulation of TET2 in human glioblastoma

Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: García, María G., Carella, Antonella, Urdinguio, Rocío G., Bayón, Gustavo F., Lopez, Virginia, Tejedor, Juan Ramón, Sierra, Marta I., García-Toraño, Estela, Santamarina, Pablo, Perez, Raúl F., Mangas, Cristina, Astudillo, Aurora, Corte-Torres, M. Daniela, Sáenz-de-Santa-María, Inés, Chiara, María-Dolores, Fernández, Agustín F., Fraga, Mario F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995234/
https://ncbi.nlm.nih.gov/pubmed/29899831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25406
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