Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

BACKGROUND: Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role in the process. METHODS: Here, we analyzed the genome-wide...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Toraño, Estela G., Bayón, Gustavo F., del Real, Álvaro, Sierra, Marta I., García, María G., Carella, Antonella, Belmonte, Thalia, Urdinguio, Rocío G., Cubillo, Isabel, García-Castro, Javier, Delgado-Calle, Jesús, Pérez-Campo, Flor M., Riancho, José A., Fraga, Mario F., Fernández, Agustín F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938941/
https://ncbi.nlm.nih.gov/pubmed/27393146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0966-x
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