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Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development

DNA methylation is a major mode of epigenetic regulation in the mammalian genome and is essential for embryonic development. The three catalytic DNA methyltransferases (Dnmts), Dnmt1, Dnmt3a, and Dnmt3b, catalyze the methylation of cytosine. Dnmt3b is highly expressed in chondrocytes and global knoc...

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Detalhes bibliográficos
Publicado no:J Cell Biochem
Main Authors: Xu, Taotao, Wang, Cuicui, Shen, Jie, Tong, Peijian, O’Keefe, Regis
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993586/
https://ncbi.nlm.nih.gov/pubmed/29637597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26775
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