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Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development

DNA methylation is a major mode of epigenetic regulation in the mammalian genome and is essential for embryonic development. The three catalytic DNA methyltransferases (Dnmts), Dnmt1, Dnmt3a, and Dnmt3b, catalyze the methylation of cytosine. Dnmt3b is highly expressed in chondrocytes and global knoc...

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Détails bibliographiques
Publié dans:J Cell Biochem
Auteurs principaux: Xu, Taotao, Wang, Cuicui, Shen, Jie, Tong, Peijian, O’Keefe, Regis
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993586/
https://ncbi.nlm.nih.gov/pubmed/29637597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26775
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