Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CII(low), serves as a checkpoint for metabolite biosynthesis under bioenergetic stress, w...

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Publicado no:Nat Commun
Main Authors: Bezawork-Geleta, Ayenachew, Wen, He, Dong, LanFeng, Yan, Bing, Vider, Jelena, Boukalova, Stepana, Krobova, Linda, Vanova, Katerina, Zobalova, Renata, Sobol, Margarita, Hozak, Pavel, Novais, Silvia Magalhaes, Caisova, Veronika, Abaffy, Pavel, Naraine, Ravindra, Pang, Ying, Zaw, Thiri, Zhang, Ping, Sindelka, Radek, Kubista, Mikael, Zuryn, Steven, Molloy, Mark P., Berridge, Michael V., Pacak, Karel, Rohlena, Jakub, Park, Sunghyouk, Neuzil, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992162/
https://ncbi.nlm.nih.gov/pubmed/29880867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04603-z
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