Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To understand why functional respiration is crucial for tumorigenesis, we used time-resolved analysis of tumor formation by mtDNA-d...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: Bajzikova, Martina, Kovarova, Jaromira, Coelho, Ana R., Boukalova, Stepana, Oh, Sehyun, Rohlenova, Katerina, Svec, David, Hubackova, Sona, Endaya, Berwini, Judasova, Kristyna, Bezawork-Geleta, Ayenachew, Kluckova, Katarina, Chatre, Laurent, Zobalova, Renata, Novakova, Anna, Vanova, Katerina, Ezrova, Zuzana, Maghzal, Ghassan J., Novais, Silvia Magalhaes, Olsinova, Marie, Krobova, Linda, An, Yong Jin, Davidova, Eliska, Nahacka, Zuzana, Sobol, Margarita, Cunha-Oliveira, Teresa, Sandoval-Acuña, Cristian, Strnad, Hynek, Zhang, Tongchuan, Huynh, Thanh, Serafim, Teresa L., Hozak, Pavel, Sardao, Vilma A., Koopman, Werner J.H., Ricchetti, Miria, Oliveira, Paulo J., Kolar, Frantisek, Kubista, Mikael, Truksa, Jaroslav, Dvorakova-Hortova, Katerina, Pacak, Karel, Gurlich, Robert, Stocker, Roland, Zhou, Yaoqi, Berridge, Michael V., Park, Sunghyouk, Dong, Lanfeng, Rohlena, Jakub, Neuzil, Jiri
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484595/
https://ncbi.nlm.nih.gov/pubmed/30449682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.014
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