Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To understand why functional respiration is crucial for tumorigenesis, we used time-resolved analysis of tumor formation by mtDNA-d...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Metab
Main Authors: Bajzikova, Martina, Kovarova, Jaromira, Coelho, Ana R., Boukalova, Stepana, Oh, Sehyun, Rohlenova, Katerina, Svec, David, Hubackova, Sona, Endaya, Berwini, Judasova, Kristyna, Bezawork-Geleta, Ayenachew, Kluckova, Katarina, Chatre, Laurent, Zobalova, Renata, Novakova, Anna, Vanova, Katerina, Ezrova, Zuzana, Maghzal, Ghassan J., Novais, Silvia Magalhaes, Olsinova, Marie, Krobova, Linda, An, Yong Jin, Davidova, Eliska, Nahacka, Zuzana, Sobol, Margarita, Cunha-Oliveira, Teresa, Sandoval-Acuña, Cristian, Strnad, Hynek, Zhang, Tongchuan, Huynh, Thanh, Serafim, Teresa L., Hozak, Pavel, Sardao, Vilma A., Koopman, Werner J.H., Ricchetti, Miria, Oliveira, Paulo J., Kolar, Frantisek, Kubista, Mikael, Truksa, Jaroslav, Dvorakova-Hortova, Katerina, Pacak, Karel, Gurlich, Robert, Stocker, Roland, Zhou, Yaoqi, Berridge, Michael V., Park, Sunghyouk, Dong, Lanfeng, Rohlena, Jakub, Neuzil, Jiri
פורמט: Artigo
שפה:Inglês
יצא לאור: 2018
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484595/
https://ncbi.nlm.nih.gov/pubmed/30449682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.014
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