Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To understand why functional respiration is crucial for tumorigenesis, we used time-resolved analysis of tumor formation by mtDNA-d...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Bajzikova, Martina, Kovarova, Jaromira, Coelho, Ana R., Boukalova, Stepana, Oh, Sehyun, Rohlenova, Katerina, Svec, David, Hubackova, Sona, Endaya, Berwini, Judasova, Kristyna, Bezawork-Geleta, Ayenachew, Kluckova, Katarina, Chatre, Laurent, Zobalova, Renata, Novakova, Anna, Vanova, Katerina, Ezrova, Zuzana, Maghzal, Ghassan J., Novais, Silvia Magalhaes, Olsinova, Marie, Krobova, Linda, An, Yong Jin, Davidova, Eliska, Nahacka, Zuzana, Sobol, Margarita, Cunha-Oliveira, Teresa, Sandoval-Acuña, Cristian, Strnad, Hynek, Zhang, Tongchuan, Huynh, Thanh, Serafim, Teresa L., Hozak, Pavel, Sardao, Vilma A., Koopman, Werner J.H., Ricchetti, Miria, Oliveira, Paulo J., Kolar, Frantisek, Kubista, Mikael, Truksa, Jaroslav, Dvorakova-Hortova, Katerina, Pacak, Karel, Gurlich, Robert, Stocker, Roland, Zhou, Yaoqi, Berridge, Michael V., Park, Sunghyouk, Dong, Lanfeng, Rohlena, Jakub, Neuzil, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484595/
https://ncbi.nlm.nih.gov/pubmed/30449682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.014
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