Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To understand why functional respiration is crucial for tumorigenesis, we used time-resolved analysis of tumor formation by mtDNA-d...

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Vydáno v:Cell Metab
Hlavní autoři: Bajzikova, Martina, Kovarova, Jaromira, Coelho, Ana R., Boukalova, Stepana, Oh, Sehyun, Rohlenova, Katerina, Svec, David, Hubackova, Sona, Endaya, Berwini, Judasova, Kristyna, Bezawork-Geleta, Ayenachew, Kluckova, Katarina, Chatre, Laurent, Zobalova, Renata, Novakova, Anna, Vanova, Katerina, Ezrova, Zuzana, Maghzal, Ghassan J., Novais, Silvia Magalhaes, Olsinova, Marie, Krobova, Linda, An, Yong Jin, Davidova, Eliska, Nahacka, Zuzana, Sobol, Margarita, Cunha-Oliveira, Teresa, Sandoval-Acuña, Cristian, Strnad, Hynek, Zhang, Tongchuan, Huynh, Thanh, Serafim, Teresa L., Hozak, Pavel, Sardao, Vilma A., Koopman, Werner J.H., Ricchetti, Miria, Oliveira, Paulo J., Kolar, Frantisek, Kubista, Mikael, Truksa, Jaroslav, Dvorakova-Hortova, Katerina, Pacak, Karel, Gurlich, Robert, Stocker, Roland, Zhou, Yaoqi, Berridge, Michael V., Park, Sunghyouk, Dong, Lanfeng, Rohlena, Jakub, Neuzil, Jiri
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484595/
https://ncbi.nlm.nih.gov/pubmed/30449682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.014
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