Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ(0) cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To determine whether the transfer of mtDNA involves whole...

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Publicado en:eLife
Autores principales: Dong, Lan-Feng, Kovarova, Jaromira, Bajzikova, Martina, Bezawork-Geleta, Ayenachew, Svec, David, Endaya, Berwini, Sachaphibulkij, Karishma, Coelho, Ana R, Sebkova, Natasa, Ruzickova, Anna, Tan, An S, Kluckova, Katarina, Judasova, Kristyna, Zamecnikova, Katerina, Rychtarcikova, Zuzana, Gopalan, Vinod, Andera, Ladislav, Sobol, Margarita, Yan, Bing, Pattnaik, Bijay, Bhatraju, Naveen, Truksa, Jaroslav, Stopka, Pavel, Hozak, Pavel, Lam, Alfred K, Sedlacek, Radislav, Oliveira, Paulo J, Kubista, Mikael, Agrawal, Anurag, Dvorakova-Hortova, Katerina, Rohlena, Jakub, Berridge, Michael V, Neuzil, Jiri
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367896/
https://ncbi.nlm.nih.gov/pubmed/28195532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22187
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