Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ(0) cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To determine whether the transfer of mtDNA involves whole...

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Vydáno v:eLife
Hlavní autoři: Dong, Lan-Feng, Kovarova, Jaromira, Bajzikova, Martina, Bezawork-Geleta, Ayenachew, Svec, David, Endaya, Berwini, Sachaphibulkij, Karishma, Coelho, Ana R, Sebkova, Natasa, Ruzickova, Anna, Tan, An S, Kluckova, Katarina, Judasova, Kristyna, Zamecnikova, Katerina, Rychtarcikova, Zuzana, Gopalan, Vinod, Andera, Ladislav, Sobol, Margarita, Yan, Bing, Pattnaik, Bijay, Bhatraju, Naveen, Truksa, Jaroslav, Stopka, Pavel, Hozak, Pavel, Lam, Alfred K, Sedlacek, Radislav, Oliveira, Paulo J, Kubista, Mikael, Agrawal, Anurag, Dvorakova-Hortova, Katerina, Rohlena, Jakub, Berridge, Michael V, Neuzil, Jiri
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367896/
https://ncbi.nlm.nih.gov/pubmed/28195532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22187
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