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Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches
β-Amyloid (Aβ) aggregation is causally linked to neuronal pathology in Alzheimer’s disease; therefore, several small molecules, antibodies, and peptides have been tested as anti-Aβ agents. We developed two compounds based on the Aβ-binding domain of transthyretin (TTR): a cyclic peptide cG8 and an e...
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| Publicado en: | ChemMedChem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991081/ https://ncbi.nlm.nih.gov/pubmed/29512286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800031 |
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