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Recent evidence that TADs and chromatin loops are dynamic structures
Mammalian genomes are folded into spatial domains, which regulate gene expression by modulating enhancer-promoter contacts. Here, we review recent studies on the structure and function of Topologically Associating Domains (TADs) and chromatin loops. We discuss how loop extrusion models can explain T...
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| Publié dans: | Nucleus |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5990973/ https://ncbi.nlm.nih.gov/pubmed/29077530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2017.1389365 |
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