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LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss

The feline model of Niemann-Pick disease, type C1 (NPC1) recapitulates the clinical, neuropathological, and biochemical abnormalities present in children with NPC1. The hallmarks of disease are the lysosomal storage of unesterified cholesterol and multiple sphingolipids in neurons, and the spatial a...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Gurda, Brittney L, Bagel, Jessica H, Fisher, Samantha J, Schultz, Mark L, Lieberman, Andrew P, Hand, Peter, Vite, Charles H, Swain, Gary P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989620/
https://ncbi.nlm.nih.gov/pubmed/29346563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlx119
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