Miglustat Improves Purkinje Cell Survival and Alters Microglial Phenotype in Feline Niemann-Pick Disease Type C

Niemann-Pick disease type C (NPC disease) is an incurable cellular lipid trafficking disorder characterized by neurodegeneration and intralysosomal accumulation of cholesterol and glycosphingolipids. Treatment with miglustat, a small imino sugar that reversibly inhibits glucosylceramide synthase, wh...

Full description

Saved in:

Bibliographic Details
Main Authors:	Stein, Veronika M., Crooks, Alexandra, Ding, Wenge, Prociuk, Maria, O’Donnell, Patricia, Bryan, Caroline, Sikora, Tracey, Dingemanse, Jasper, Vanier, Marie T., Walkley, Steven U., Vite, Charles H.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3352323/ https://ncbi.nlm.nih.gov/pubmed/22487861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e31825414a6
Tags:	Add Tag No Tags, Be the first to tag this record!

Miglustat Improves Purkinje Cell Survival and Alters Microglial Phenotype in Feline Niemann-Pick Disease Type C

Similar Items