One-step, stereoselective synthesis of octahydrochromanes via the Prins reaction and their cannabinoid activities

Novel, functionalized octahydrochromene derivatives were synthesized in a single step via the Prins reaction. Enantiomerically pure (+)-isopulegol was reacted with benzaldehyde to stereoselectively yield the corresponding octahydro-2H-chromen-4-ol derivative containing five stereocenters. A total of...

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Veröffentlicht in:Tetrahedron Lett
Hauptverfasser: Slater, Shuneize, Lasonkar, Pradeep B., Haider, Saqlain, Alqahtani, Moneerah J., Chittiboyina, Amar G., Khan, Ikhlas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986293/
https://ncbi.nlm.nih.gov/pubmed/29880989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2018.01.040
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