Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase

AIM: There is little information available on the monoamine oxidase isoform selectivity of N-alkyl harmine analogs, which exhibit a myriad of activities including MAO-A, DYRK1A and cytotoxicity to several select cancer cell lines. RESULTS: Compounds 3e and 4c exhibited an IC(50) of 0.83 ± 0.03 and 0...

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Detalhes bibliográficos
Publicado no:Future Med Chem
Main Authors: Haider, Saqlain, Alhusban, Manal, Chaurasiya, Narayan D, Tekwani, Babu L, Chittiboyina, Amar G, Khan, Ikhlas A
Formato: Artigo
Idioma:Inglês
Publicado em: Future Science Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021913/
https://ncbi.nlm.nih.gov/pubmed/29788780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2018-0006
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