Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

Pathways of human epidermal growth factor (EGF) receptors are activated upon ligand-dependent or -independent homo- or heterodimerization and their subsequent transphosphorylation. Overexpression of these receptors positively correlates with transphosphorylation rates and increased tumor growth rate...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Oganesyan, Vaheh, Peng, Li, Bee, Jared S., Li, John, Perry, Samuel R., Comer, Frank, Xu, Linda, Cook, Kimberly, Senthil, Kannaki, Clarke, Lori, Rosenthal, Kim, Gao, Changshou, Damschroder, Melissa, Wu, Herren, Dall'Acqua, William
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986207/
https://ncbi.nlm.nih.gov/pubmed/29669810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.818013
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