Long-acting antibody ligand mimetics for HER4-selective agonism

Neuregulin protein 1 (NRG1) is a large (> 60–amino-acid) natural peptide ligand for the ErbB protein family members HER3 and HER4. We developed an agonistic antibody modality, termed antibody ligand mimetics (ALM), by incorporating complex ligand agonists such as NRG1 into an antibody scaffold. W...

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Vydáno v:Sci Rep
Hlavní autoři: Shan, Lu, Cook, Kimberly M., Haskins, Nantaporn, Omar, Bilal, Jiang, Yu, Garcia, Andrew, Koksal, Adem, Oganesyan, Vaheh, Rosenthal, Kim, Wu, Herren, Dall’Acqua, William F., Damschroder, Melissa M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566517/
https://ncbi.nlm.nih.gov/pubmed/33057063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74176-9
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